Pathologic 3 Hospital Guide: Diagnoses, Samples, and Vaccine Protocols

A hospital shift in Pathologic 3 is won before you press the diagnosis key. You need to notice what the patient looks like during the interview, inspect the right side of the body, separate old injuries from the current illness, and reserve a reagent for the one organ system that can break a tie. A correct label is irreversible once locked, and the work is not credited until you collect the results back at Stillwater.

This guide covers the hospital chain from its Day 3 setup through the last regular cases on Day 10. It gives the verified diagnosis roster, but it also explains how to reach those answers when patient order, localization, or a later patch changes what you see. It does not attempt a twelve-day story route, every decree, every ending, or a 100% achievement schedule.

Make every case pass through the same diagnostic loop#

Do not begin by selecting every symptom that sounds plausible. That creates a crowded Casebook and can remove the useful follow-up questions. Work in this order:

1. Read the face before leaving dialogue. Red eyes, pallor, lesions, and other visible signs can be easy to miss after the view changes. Add only what is actually visible or stated.
2. Examine both sides of the body. Chest and back, both arm angles, and both leg angles can expose different signs. Sweep slowly with Concentration instead of assuming the front view is enough.
3. Question the patient again. A mark becomes useful when it opens a statement about onset, occupation, diet, water, travel, or whether a sign predates the illness. Remove signs that the interview or environment explains away.
4. Compare the remaining diagnoses by body system. Use the question-mark detail beside each candidate. Find one system where the candidates disagree: CNS, vision, mucous membranes, respiratory, circulatory, skin, or gastrointestinal.
5. Sample that separating system. A microscope result is most valuable when one possible illness infects the chosen system and the other does not. Sampling a system shared by every candidate spends reagent without resolving anything.
6. Do the patient investigation when the Casebook still says the answer needs work. The home, workplace, relatives, or witnesses may prove that an apparent sign came from insects, work, violence, alcohol, steppe plants, or an earlier condition.
7. Lock only after the evidence agrees. Once the diagnosis is confirmed in the Casebook, it cannot be edited. If the label is still uncertain, leave it open and finish the missing investigation first.

The microscope itself has two focus steps. Move through depth until the first audio cue identifies the layer, locate the moving red cells, then adjust magnification until the second cue. Track the cells until the meter fills. If the meter stays still while the cells are centered, make a small depth or zoom correction instead of abandoning the sample.

Reagent is made from Belladonna and Novocaine. A hospital cabinet can also contain reagent even when it fails to glow. In the office, search the storage beside the paper bull; it sits in the narrow space separating the clock from the desk. Do that before spending time on another trip.

Use Day 3 to create a working hospital, not a perfect policy#

The hospital chain begins with the Town Hall meeting on Day 3. Follow the medical proposal, accept the help you intend to use, and inspect the proposed sites. The supported route resolves at the Theatre in the Marrow: speak with Mark inside, secure the building, then report the choice at Town Hall.

Finish the laboratory tutorial at Stillwater rather than leaving the hospital as a map marker. Analyze the collected sample, prepare the test vaccine from the dancer’s blood, and open the decree board. This establishes the three linked systems that matter for the rest of the run:

• The hospital produces diagnoses and patient investigations.
• The Stillwater laboratory handles samples, medicine, the Prototype, and daily result papers.
• The decree board turns successful research into protocols that push the town’s collapse farther away.

Do not spend every reagent during the tutorial. Beginning with the regular roster, several cases deliberately present overlapping illnesses. Keep Belladonna and Novocaine available, and remember that medicine mixing does not advance the clock while microscope analysis does.

The verified diagnosis roster for Days 4–10#

The table is a recovery tool, not a reason to skip the examination. Patient investigations, samples, and dialogue can unlock story knowledge beyond the final label. They also protect you if a patch changes the order or if the Casebook contains a version-specific disease name.

Day	Patient	Diagnosis in the checked build	Best confirmation step
4	Luta	Anemic Vasculopathy	Connect fever with pallor and hematomas; the boiler-room history helps frame the case.
	Finch	Burning Fever	Separate occupational skin changes from illness; yellowing is not the deciding sign.
	Filat	Nephropathia epidemica	Search his room in the Skinners. The environmental investigation supplies the symptoms that the hospital exam cannot settle.
5	Oktay	Stoneskin	Speak with the Herb Brides for the slow-pulse clue and do not treat every plant-related skin sign as disease.
	Bobok	Burning Fever	Use the Casebook order shown in your current cycle; some records display Bobok and Oktay in a different order.
	Sharp	Consumption	Question the cough, then test the relevant respiratory or mucous-membrane evidence rather than accepting bruising as causal.
6	Hardman	Ink Syndrome	Difficulty breathing, hallucinations, and vein damage matter more than the suspected water story by itself.
	Grouse	Steppe Gastrodermal Fever	Keep the gastrointestinal cluster together and discard skin redness explained by contact with herbs.
	Gannet	Bradycardia in one maintained reference; Fruit Typhoid in another build/reference	Do not force either label. Compare the currently displayed candidates against the vision, respiratory, circulatory, skin, and gastrointestinal microscope pattern.
	Burdock	Influenza	Complete the Warehouses investigation and use a gastrointestinal sample to remove the close alternatives.
7	Emilia	Bonkowski’s Fever	Her off-site investigation converts a vague weakness and hallucination case into a usable nervous-system history.
	Martin	Pulmomucous Syndrome	Do not let old skin peeling dominate the active mucous-membrane, respiratory, and coordination signs.
	Tuutey	Ink Syndrome	Use a sample when the observed vein and eye signs leave more than one candidate; the respiratory or skin pattern can break the tie.
8	Astrild	Measles	Her fever and skin redness need the wider multi-system pattern; unrelated ulcers should not stay selected.
	Crow	Steppe Dryness	Use the gastrointestinal sample to distinguish it from Influenza when their visible signs overlap.
	Petrel	Hepatitis	Test the systems that separate Hepatitis from Influenza and Steppe Gastrodermal Fever; his unreliable sense of time is not itself the diagnosis.
	Tawpie	Tularemia	Follow the Atrium-to-Shekhen investigation. It identifies the marks as insect bites and establishes the steppe exposure.
9	Patchwork	Measles	He denies useful symptoms; speak with his children for the sore-throat evidence.
	Aristarkh	Hepatitis	Separate current weakness, dystrophy, and yellowing from hematomas that are not part of the illness.
	Sakh Man	Twyrine Syndrome	Use the nervous-system and vision history with the uncertain age of the vein damage.
	Sergeant Dronte	Anemic Vasculopathy	Discard ulcers and skin redness explained by digging; retain the fever, headache, pallor, and relevant system pattern.
10	Yakov Little	Serpent Syndrome	Check the respiratory, skin, gastrointestinal, and vision signs; the circulatory pattern is the useful exclusion.
	Kira	Acute Bronchopathy	Return to the hospital in the evening even if no message appears, then complete the Chine household investigation before locking the case.

Treat the three investigative cases as route gates#

Most patients can be resolved inside the hospital. Filat, Tawpie, and Kira are different: the absent evidence is the point of the case.

Filat on Day 4: prove what the examination cannot

After the initial interview and body scan, tell Filat you need to inspect his home. Travel to the Skinners, get access to his room, and examine the bathroom and the evidence in the bedroom. The useful outcome is not merely a longer symptom list. It is a set of exclusions: some apparent clues came from something other than his present disease, while the new nervous-system, gastrointestinal, and circulatory information makes Nephropathia epidemica defensible.

You can lock the diagnosis from the Casebook once the investigation has supplied the missing evidence; a physical return to the hospital is not required just to press the final confirmation.

Tawpie on Day 8: distinguish exposure from contagion

Begin in the Atrium at the house near the Stairway to Heaven and Hypat’s cart. Speak with the child outside. The family pattern and the patient’s recent steppe activity point away from ordinary household spread. Continue to Shekhen, keep left past the bull pen, and inspect the objects in the relevant tent with Concentration. That evidence explains the red marks as insect bites and supports Tularemia.

If the route marker or local geometry differs after an update, preserve the logic: confirm the patient’s food or steppe exposure, establish whether relatives share the condition, and identify the cause of the skin marks before choosing a disease.

Kira on Day 10: the second patient can arrive without a clean prompt

Diagnose Little first, then continue the day. Kira is an evening case. An official hotfix moved her appearance earlier, while community references still describe a possible missing notification or invisible hospital model. If no message arrives, return to the Theatre after 6 PM and open the Casebook before assuming the chain has failed.

Her investigation begins at the house in the south of the Chine. Inspect the kitchen and bedroom, including the easy-to-miss beetle beside the bed. Work through the doll conversation until the tea-party conclusion is available, then speak with the household again. Upstairs, the boy adds the headache and respiratory history. Leave through the back, turn right along the river, and find the group that can reveal the remaining mucous-membrane sign. The complete pattern supports Acute Bronchopathy.

Day 9 surgery is a separate urgent case#

The Katerina operation is not one of the four normal Day 9 Casebook patients. Prepare for it on earlier days instead of treating it as another label in the table. The strongest verified route has four prerequisites:

• Keep Rubin and Artemy available to assist.
• Build a record of correct diagnoses and vaccine work before Day 9.
• Deal with infection sources often enough that the operation recognizes the town’s medical progress; community reports conflict on the exact day count, so verify the resulting condition in your own objective state.
• Carry non-morphine sedatives instead of planning to improvise them after the summons.

Examine Katerina’s lower abdomen from the front; without that observation, the ovarian-cyst diagnosis is unavailable. Use Yulia as the blood donor. If you are racing the first cycle, test her at the mobile lab west of the Saburov house rather than detouring to Stillwater. A practical sedative load is Meradorm plus one or two Bromide, adjusted to the live surgery interface.

Do not copy an old bandit-loot route to obtain those sedatives. Update #6 reduced bandit rewards, and the maintained guide flags that weak sedatives now need to be traded for or mixed. Prepare the medicine before the day starts.

The result paper is the real end of a hospital shift#

A correct set of labels is unfinished work until Stillwater records it. Return to the downstairs laboratory after the results become available. Current references place the result interaction after 5 PM, while another guide describes it as after 6 PM; the safe rule is to check after 6 PM. Interact with the papers on the side table near the orderly, between the ingredient chest and the Prototype equipment.

If the orderly is present but the next vaccine protocol does not appear, check these states before replaying the entire day:

1. Open the Casebook and confirm that every daily patient has a locked diagnosis.
2. Return to the hospital for any patient whose file still says the case requires investigation.
3. Check whether an evening patient, especially Kira, was added without a notification.
4. Interact with the result papers themselves; speaking to the orderly is not always the collection action.
5. Open the decree board and look for the newly unlocked vaccine protocol before assuming it failed.

The protocol belongs on the decree board only after you inspect its current costs and effects. Old guide numbers are especially fragile because the developer has announced a balance update. Use the vaccine protocol to control contagion, then compare the resulting unrest and available supplies with the other decrees already scheduled. A large infection reduction is not a win if a crossed-out resource cost prevents the decree from firing.

Recover from a bad diagnosis without wasting Amalgam#

If a locked answer is wrong, restarting the current day creates another cycle without the same cost as traveling to a different day. Before restarting, note what failed: a missed body angle, an unexplained symptom, a sample taken from a system shared by both candidates, or an incomplete patient quest.

On the next cycle, go straight to the missing evidence. Containers and some profile-level resources do not necessarily reset the way a conventional save does, so do not assume a restart restores every reagent or item. Keep critical ingredients in known storage, check the clock inventory before traveling, and collect the result paper again after the corrected roster.

For Gannet, do not restart merely because an external list uses a different disease name. The current sources disagree between Bradycardia and Fruit Typhoid, and the maintained Steam guide explicitly treats it as a version difference. The success condition is the label supported by your build’s candidate list and microscope pattern.

Sources & credits#

Game identity, release status, screenshots, update history, and the announced balance boundary were checked against the official Steam store page and developer news. Diagnostic mechanics, patient rosters, investigation routes, and failure states were cross-checked against readable community guides, including the English Steam Guides hub. Pathologic 3: Quarantine is a separate free prelude with App ID 3389330; its scenes and commands were not used as evidence for this full-game hospital route.